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Matthew W. Mosconi, Ph.D.

College of Liberal Arts and Sciences - Clinical Child Psychology Program, Schiefelbusch Institute for Lifespan Studies, Departments of Applied Behavioral Science and Psychology
Associate Professor, Clinical Child Psychology
Director, Kansas Center for Autism Research and Training (K-CART)
Primary office:
Dole Human Development Center
Room 2018
University of Kansas
Second office:
Wakarusa Research Facility
Room 108



Summary

Dr. Mosconi completed his Ph.D. in Clinical Psychology and an APA-approved Clinical Internship at the University of North Carolina – Chapel Hill. He then performed his postdoctoral training in developmental cognitive neuroscience and pediatric neuropsychology at the University of Illinois in Chicago. Dr. Mosconi joined the faculty in Psychiatry at the University of Illinois in Chicago from 2009-2011, moved onto the faculty at the University of Texas Southwestern Medical Center from 2011-2015, and joined the faculty at the University of Kansas in August, 2015. He currently is the Director of the Kansas Center for Autism Research and Training (K-CART), Associate Professor of Psychology and Applied Behavioral Science, and Associate Scientist in the Life Span Institute. Dr. Mosconi’s research is focused on sensorimotor dysmaturation and underlying brain mechanisms in neurodevelopmental disorders, including autism spectrum disorder, Phelan-McDermid Syndrome, and FMR1 related disorders. His work has been supported by NIH (NIMH, NINDS, NICHD), the Department of Defense, Autism Speaks, the Phelan-McDermid Syndrome Foundation and the Once Upon A Time Foundation. He has published in multiple high impact journals including JAMA Psychiatry, the Journal of Neuroscience, Journal of Neurophysiology, Molecular Autism, NeuroImage and Biological Psychiatry. Dr. Mosconi serves on the editorial boards of the Journal of Autism and Developmental Disorders Research in Autism Spectrum Disorders, and Frontiers in Integrative Neuroscience.

Teaching Interests

  • Autism
  • Developmental cognitive neuroscience
  • Assessment of developmental disabilities

Research

Dr. Mosconi’s research examines sensorimotor, cognitive and brain development in autism spectrum and related intellectual/developmental disorders, including Phelan-McDermid Syndrome and Fragile X Syndrome. He also currently is conducting studies on neurodegenerative disorders characterized by deterioration of sensorimotor skills, such as Fragile X-associated tremor/ataxia syndrome (FXTAS). The aim of this research program is to determine the brain mechanisms that contribute to sensorimotor and cognitive impairments in developmental disorders. This knowledge then may be used for multiple purposes: 1) To identify new behavioral and brain targets for the development of more precise and effective therapeutic approaches; 2) To generate translational biobehavioral markers that can measured in clinical trials validating new treatment approaches, and; 3) To create biobehavioral measures that may assist in more reliable identification approaches for young children with autism. Dr. Mosconi’s studies integrate quantitative behavioral measurements, neuropsychological assessment, and systems neuroscience techniques including functional MRI, diffusion tensor imaging (DTI), electromyography (EMG), electroencephalography (EEG), kinematic and kinetic analysis and oculomotor recording.

Research Interests

  • Autism
  • Sensorimotor
  • Cerebellum
  • Functional MRI
  • EEG
  • Child psychology
  • Fragile X
  • Phelan-McDermid Syndrome
  • Fragile X Associated Tremor/Ataxia Syndrome (FXTAS)
  • Repetitive behaviors
  • Insistence on sameness
  • Clinical Psychology

Selected Publications

Ethridge L, Berry-Kravis E, Thaliath A, Isenstein, E, Durkin A, Nelson C, Baczewsi L, Powell C, White S, Mosconi MW, . . . Sweeney, J. (2018). 21. Auditory EEG Phenotypes in Single Gene Disorders: Insight into Heterogeneity in Idiopathic Autism. Biological Psychiatry. 83(9, Supplement), S8-S9. doi:https://doi.org/10.1016/j.biopsych.2018.02.038 ISI=10.58

Montgomery AK, Shuffrey LC, Guter SJ, Anderson GA, Jacob S, Mosconi MW, Sweeney JA, Turner JB, Sutcliffe JS, Cook EH, Veenstra-VanderWeele. (in press). Maternal serotonin levels are associated with cognitive ability and core symptoms in autism spectrum disorder. Journal of the American Academy of Child and Adolescent Psychiatry. ISI=7.86

Schmitt LM, White SP, Cook EH, Sweeney JA, Mosconi MW. Cognitive mechanisms of inhibitory control deficits in autism spectrum disorder (ASD). (2017). Journal of Child Psychology and Psychiatry. 59(5):586-595. doi: 10.1111/jcpp.12837 ISI=6.68

Ethridge LE, White SP, Mosconi MW, Wang J, Pedapati EV, Erickson CA, Byerly MJ, Sweeney JA. (2017). Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in Fragile X Syndrome. Molecular Autism. 8(22): doi: 10.1186/s13229-017-0140-1 ISI=6.08

Shou G, Mosconi MW, Wang J, Ethridge L, Sweeney JA, Ding L. (2017). Electrophysiological signatures of atypical intrinsic brain connectivity networks in autism. Journal of Neural Engineering. 14(4):046010. doi: 10.1088/1741-2552/aa6b6b ISI=3.49

Wang J, Ethridge LE, Mosconi MW, White SP, Binder DK, Pedapati EV, Erickson CA, Byerly MJ, Sweeney JA. (2017). A resting EEG study of neocortical hyperexcitability and altered functional connectivity in fragile X syndrome. Journal of Neurodevelopmental Disorders. 9:11. doi: 10.1186/s11689-017-9191-z ISI=3.85

Wang Z, Kwon MH, Mohanty S, Schmitt LM, White SP, Christou EA, Mosconi MW. (2017). Increased force variability is associated with altered modulation of motoneuron pool activity in autism spectrum disorder (ASD). International Journal of Molecular Sciences. 18:698. doi:10.3390/ijms18040698 ISI=3.26

Schmitt LM, Ankeny LD, Sweeney JA, Mosconi MW. (2017). Inhibitory control processes and the strategies that support them during hand and eye movements. Frontiers in Psychology: Cognition. ISI=2.46 (2016; 5 year ISI is not yet available)

Wang Z, Hallac R, Conroy KC, White SP, Kane AA, Collinsworth AL, Sweeney JA, Mosconi MW. (2017). Postural orientation and equilibrium processes associated with increased postural sway in autism spectrum disorder (ASD). Journal of Neurodevelopmental Disorders. 8:43. ISI=3.85

Selected Presentations

Wang, Z. Khemani, P. & Mosconi, M. W. (11/30/2017). Postural control deficits in aging Fragile X mental retardation 1 (FMR1) gene premutation carriers. Society for Neuroscience (SfN). Washington DC

Bojanek, E. Schmitt, L. M., White, S. P., Sweeney, J. A. & Mosconi, M. W. (05/31/2017). Behavioral response inhibition deficits in children with autism spectrum disorder and their parents. International Meeting for Autism Research (IMFAR). San Francisco, CA.

DeStefano, L. Wang, J. White, S. P., Mosconi, M. W., Sweeney, J. A. & Ethridge, L. E. (11/30/2016). Auditory neural oscillatory synchronization abnormalities across the gamma frequency range in autism spectrum disorder. Society for Psychophysiological Research. Minneapolis, MN

Ethridge, L. E., White, S. P., Mosconi, M. W., Wang, J. Erickson, C. A., Byerly, M. J. & Sweeney, J. A. (11/30/2016). Neural synchronization deficits linked to cortical hyper-excitability and auditory sensitivity in Fragile X Syndrome. Society for Psychophysiological Research. Minneapolis, MN

Mosconi, M. W. (11/30/2016). Understanding autism: stories of politics, fads and the brain. University of Kansas Nu Rho Psi HonorΓÇÖs Society. Lawrence, Kansas

Mosconi, M. W. (10/31/2016). Motor and sensory disturbances and their brain bases in autism spectrum disorder. University of Kansas Child Language Program Professional Seminar Series. Lawrence, Kansas

Mosconi, M. W., Schmitt, L. M., White, S. P. & Sweeney, J. A. (09/30/2016). Brain system abnormalities associated with reduced control of sustained and repetitive motor behaviors. National Conference in Clinical Child and Adolescent Psychology (NCCCAP). Lawrence, KS

Wang, Z. Hallac, R. Conroy, K. C., White, S. P., Kane, A. A., Collinsworth, A. L. & Mosconi, M. W. (09/30/2016). Postural orientation and equilibrium are manifested in autism spectrum disorder (ASD). National Conference in Clinical Child and Adolescent Psychology (NCCCAP). Lawrence, KS

Schmitt, L. M., White, S. P., Sweeney, J. A. & Mosconi, M. W. (09/30/2016). Sensorimotor Abnormalities in Individuals with Autism Spectrum Disorder and Their Biological Parents. National Conference in Clinical Child and Adolescent Psychology. Lawrence, KS

Mosconi, M. W. (07/31/2016). What we think we think about thinking in Phelan-McDermid Syndrome. First Annual Phelan-McDermid Syndrome National Meeting (McPosium). . Orlando, FL

Mosconi, M. W., Schmitt, L. M., White, S. P. & Sweeney, J. A. (05/31/2016). Brain system abnormalities associated with reduced control of sustained and repetitive motor behaviors in autism. International Meeting for Autism Research (IMFAR). Baltimore, MD

Kwon, M. Mohanty, S. Conroy, K. C. & Mosconi, M. W. (05/31/2016). Increased Force Variability in Autism Reflects Reduced Modulation of Motor Neuron Pool Beta Oscillations. International Meeting for Autism Research (IMFAR). Baltimore, MD

Wang, Z. Hallac, R. Conroy, K. C., White, S. P., Kane, A. A., Collinsworth, A. L. & Mosconi, M. W. (05/31/2016). Postural control mechanisms underlying reduced stability in autism spectrum disorder (ASD). International Meeting for Autism Research (IMFAR). Baltimore, MD

Schmitt, L. M., White, S. P., Conroy, K. Sweeney, J. A. & Mosconi, M. W. (05/31/2016). Sensorimotor abnormalities in biological mothers and fathers of individuals with ASD. International Meeting for Autism Research (IMFAR). Baltimore, MD

Mosconi, M. W. (04/30/2016). Characterizing the development of fundamental sensorimotor abilities and underlying brain systems in autism spectrum disorder. Department of Psychiatry Grand Rounds - Vanderbilt University. Department of Psychiatry Grand Rounds - Vanderbilt University

Mosconi, M. W., Schmitt, L. M., White, S. P., Conroy, K. & Sweeney, J. A. (12/31/2015). Familiality of sensorimotor alterations in autism spectrum disorder. American College of Neuropsychopharmacology (ACNP). Hollywood, FL

Mosconi, M. W. (11/30/2015). Moving towards more effective treatments for autism spectrum disorders. Annual Retreat for the University of Kansas Medical Center Department of Pediatrics. Kansas City, KS

Mosconi, M. W. (10/31/2015). Understanding the neurobiology of autism spectrum disorders through clinical research. Beyond the Diagnosis: Autism Across the Life Span. Kansas City, KS

Mosconi, M. W. (06/30/2015). Clinical and translational approaches for understanding Phelan-McDermid Syndrome. Texas-Louisiana Phelan-McDermid Syndrome Conference. Houston, TX

Mosconi, M. W., Vaillancourt, D. E. & Sweeney, J. A. (05/31/2015). Cerebellar alterations underlying visuomotor deficits in autism. Presentation, International Meeting for Autism Research (IMFAR). Salt Lake City, UT

Schmitt, L. M., White, S. P., Conroy, K. Sweeney, J. A. & Mosconi, M. W. (05/31/2015). Eye movement abnormalities in individuals with autism and their unaffected biological parents. Presentation, International Meeting for Autism Research (IMFAR). Salt Lake City, UT

Mohanty, S. Neely, K. A., Schmitt, L. M., Wang, Z. Vaillancourt, D. E., Sweeney, J. A. & Mosconi, M. W. (05/31/2015). Precision grip control with and without visual feedback in autism spectrum disorder. Presentation, International Meeting for Autism Research (IMFAR). Salt Lake City, UT

Wang, Z. Hallac, R. Conroy, K. A., Greene, R. K., White, S. P., Sweeney, J. A. & Mosconi, M. W. (05/31/2015). Sensory feedback mechanisms underlying postural control abnormalities in individuals with autism spectrum disorder (ASD). Presentation, International Meeting for Autism Research (IMFAR). Salt Lake City, UT

Ethridge, L. E., White, S. P., Mosconi, M. W., Wang, J. Byerly, M. J. & Sweeney, J. A. (05/31/2015). Sensory processing abnormalities, ASD features, and modulation of auditory evoked potentials in Fragile X Syndrome. Presentation, International Meeting for Autism Research (IMFAR). Salt Lake City, UT

Mosconi, M. W. (03/31/2015). Advancing care through research: How studies of brain and motor development in autism may lead to earlier diagnosis and more effective treatments. Inaugural Keynote Lecture, Friends of the Center for Autism and Developmental Disabilities. Dallas, TX

Mosconi, M. W. (01/31/2015). Translational approaches for identifying neural mechanisms in autism related disorders. Talk, University of Texas Southwestern Clinical Research Engagement Workgroup (CREW) Lunch Series. Dallas, TX

Mosconi, M. W., Vaillancourt, D. E. & Sweeney, J. A. (12/31/2014). Cortico-cerebellar dysfunctions associated with visuomotor abnormalities in autism spectrum disorder vary according to the quality of visual feedback. Presentation, American College of Neuropsychopharmacology (ACNP). Phoenix, AZ

Mosconi, M. W., Vaillancourt, D. E., Coombes, S. A. & Sweeney, J. A. (11/30/2014). Cortical-cerebellar abnormalities underlying visuomotor control deficits in autism spectrum disorder. Presentation, Society of Neuroscience (SfN). Washington, DC

Wang, Z. Magnon, G. C., Greene, R. K., Sweeney, J. A. & Mosconi, M. W. (11/30/2014). Predictive and reactive precision grip force control in individuals with autism spectrum disorder. Presentation, Society of Neuroscience (SfN). Washington, DC

Mosconi, M. W. (10/31/2014). Neuroscience and early detection of autism spectrum disorder. Talk, Psychiatry Continuing Education Program: Brain Stories, the Science Behind Prevention, Early Detection, and Effective Intervention for Mental Illness, Department of Psychiatry, University of Texas Southwestern. Dallas, TX

Mosconi, M. W. (09/30/2014). Cerebellar and sensorimotor development in autism. Talk, University of Minnesota Center for Cognitive Science (CCS) Colloquium Series. Minneapolis, MN

Mosconi, M. W. (09/30/2014). Profiles of sensorimotor impairments in autism spectrum disorder. Talk, University of Minnesota Center for Neurobehavioral Development (CNBD) Colloquium Series. Minneapolis, MN

Mosconi, M. W. (07/31/2014). Sensorimotor and cerebellar abnormalities in Phelan-McDermid Syndrome. Talk, The 14th Annual Phelan-McDermid Syndrome Foundation Conference. Orlando, FL

Ouyang, M. Cheng, H. Gong, G. Mosconi, M. W., Sweeney, J. A., Peng, Y. & Huang, H. . (05/31/2014). Abnormal WM microstructural trajectories of autistic children from 2 to 7 years of age. Presentation, The International Society for Magnetic Resonance in Medicine (ISMRM). Milan, Italy

Schmitt, L. M., Mosconi, M. W., Ragozzino, M. E., Cook, E. H. & Sweeney, J. A. (05/31/2014). Neurocognitive strategies supporting behavioral response inhibition in autism spectrum disorder. Presentation, International Meeting for Autism Research (IMFAR). Atlanta, GA

Mosconi, M. W. (01/31/2014). Examining the effects of premutations and full mutations of the FMR1 gene on behavior and brain function. Talk, The Center for Autism and Developmental Disabilities (CADD) Annual Fragile X Day, UT Southwestern and ChildrenΓÇÖs Medical Center. Dallas, TX

Selected Grants

Frontiers Trailblazer Award

Mosconi (PI)
09/01/17-06/30/18

Sensory and motor physiology in autism spectrum disorder

This award aims to support EEG studies of cortical physiology during sensorimotor processing in individual with autism spectrum disorder (ASD). It is supported by an NIH Clinical and Translational Science Award grant (UL1 TR002366) awarded to the University of Kansas Medical Center.
Role: PI

R01 MH112734-01
Mosconi (PI)
07/01/17-05/31/22

Motor abnormalities and functional brain mechanisms in autism spectrum disorder

This five-year R01 study will identify the distinct neural processes underlying rapid, repetitive sensorimotor abnormalities and deficits in controlling continuous motor output. Novel functional magnetic resonance imaging (fMRI) and motor physiology tests will be conducted to examine cerebellar-cortical and striatal-cortical brain function and their relation to sensorimotor abnormalities in ASD from late childhood to adulthood.
Role: PI
 

P30 HD002528
Colombo (PI)
07/01/15-06/30/20

Kansas Intellectual and Developmental Disabilities Research Center (KIDDRC)

The Kansas Intellectual and Developmental Disabilities Research Center (KIDDRC), now in its 44th year, provides Core support for generating effective biobehavioral interventions aimed at the causes, prevention, and treatment of intellectual and developmental disabilities and related secondary conditions, and in delineating basic knowledge of the underlying biology of typical and atypical development.
Role: Co-Investigator
 

U54 NS092090
Sahin (PD)
01/01/14-08/31/19

Rare Diseases Clinical Research Network: Developmental Synaptopathies Consortium

The aim of this five year project is to clinically characterize three rare genetic syndromes associated with autism spectrum disorder (ASD), including Phelan-McDermid Syndrome, PTEN mutation and Tuberous Sclerosis. The study’s long-term goal is to identify biomarkers that can be used to develop and validate new therapies for these rare disorders and possibly ASD more broadly.
Role: Consultant
 

K01 MH107774
Miller (PI)
05/01/17-04/30/22

Visuomotor integration and attention in autism spectrum disorder (ASD)

The goal of this K01 resubmission is to examine differences between children with ASD and typically developing children in key aspects of visuomotor integration using an innovative paradigm that allows precise quantification of unrestricted head, eye, and body movement during controlled tasks in a semi-naturalistic environment
Role: Co-Mentor
 

K23 MH112936
Pedapati (PI)
02/01/17-01/31/22

Transcranial magnetic stimulation and neocortical excitability in Fragile X Syndrome

The central hypothesis of this K23 Career Development Award posits that variations in motor cortical excitability, including measures of sensorimotor habituation, can be reliably quantified in individuals with Fragile X Syndrome and may serve as a translational biomarker to predict prognostic features and guide novel treatment strategies in patients. The candidate proposes to adapt fundamental transcranial magnetic stimulation measurement techniques to the FXS population to measure excitability in the primary motor cortex.
Role: Contributor
 

TL1 TR002368
Unruh (PI)
09/07/17-06/30/19

Systems neuroscience approaches to studying sensorimotor behavior in autism

The purpose of this TL1 Career Development Program Award (KUMC Frontiers CTSA) is to develop expertise in systems neuroscience approaches for understanding the complex neural processes and network connectivity that underlie mechanisms of restricted and repetitive behaviors in autism spectrum disorder (ASD). The candidate proposes studies of sensorimotor control that will assess the neural network responsivity (functional magnetic resonance imaging) and dynamic cortical interactions (electroencephalography) that may contribute to increased variability observed during feedback-guided motor behavior in ASD.
Role: Mentor


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