Matthew W. Mosconi, Ph.D.

College of Liberal Arts and Sciences - Applied Behavioral Science, Life Span Institute, Psychology
Associate Professor, Associate Scientist
Primary office:
Dole Human Development Center
University of Kansas
1000 Sunnyside Avenue
Lawrence, KS 66045


Dr. Mosconi completed his Ph.D. in Clinical Psychology and an APA-approved Clinical Internship at the University of North Carolina – Chapel Hill. He then performed his postdoctoral training in developmental cognitive neuroscience and pediatric neuropsychology at the University of Illinois in Chicago. Dr. Mosconi joined the faculty in Psychiatry at the University of Illinois in Chicago from 2009-2011, moved onto the faculty at the University of Texas Southwestern Medical Center from 2011-2015, and joined the faculty at the University of Kansas in August, 2015. He currently is an Associate Professor of Psychology and Applied Behavioral Science, and Associate Scientist in the Life Span Institute. Dr. Mosconi’s research is focused on sensorimotor dysmaturation and underlying brain mechanisms in neurodevelopmental disorders, including autism spectrum disorder, Phelan-McDermid Syndrome, and FMR1 related disorders. His work has been supported by NIH (NIMH, NINDS, NICHD), the Department of Defense, Autism Speaks, the Phelan-McDermid Syndrome Foundation and the Once Upon A Time Foundation. He has published in multiple high impact journals including JAMA Psychiatry, the Journal of Neuroscience, Journal of Neurophysiology, Molecular Autism, NeuroImage and Biological Psychiatry. Dr. Mosconi serves on the editorial boards of the Journal of Autism and Developmental Disorders and Current Developmental Disorders Reports. He was the recipient of the International Society for Autism Research (INSAR) 2014 Young Investigator Award.

Education

Ph.D., Child Clinical Psychology, University of North Carolina – Chapel Hill

B.A., Psychology/English, Emory University

Teaching Interests

  • Autism
  • Developmental cognitive neuroscience
  • Assessment of developmental disabilities

Research

Dr. Mosconi’s research examines sensorimotor, cognitive and brain development in autism spectrum and related intellectual/developmental disorders, including Phelan-McDermid Syndrome and Fragile X Syndrome. He also currently is conducting studies on neurodegenerative disorders characterized by deterioration of sensorimotor skills, such as Fragile X-associated tremor/ataxia syndrome (FXTAS). The aim of this research program is to determine the brain mechanisms that contribute to sensorimotor and cognitive impairments in developmental disorders. This knowledge then may be used for multiple purposes: 1) To identify new behavioral and brain targets for the development of more precise and effective therapeutic approaches; 2) To generate translational biobehavioral markers that can measured in clinical trials validating new treatment approaches, and; 3) To create biobehavioral measures that may assist in more reliable identification approaches for young children with autism. Dr. Mosconi’s studies integrate quantitative behavioral measurements, neuropsychological assessment, and systems neuroscience techniques including functional MRI, diffusion tensor imaging (DTI), electromyography (EMG), electroencephalography (EEG), kinematic and kinetic analysis and oculomotor recording. He is accepting applications for new graduate students for the 2016-2017 academic year.

Research Interests

  • Autism, sensorimotor, cerebellum, functional MRI, EEG, child psychology, Fragile X, Phelan-McDermid Syndrome, Fragile X Associated Tremor/Ataxia Syndrome (FXTAS), repetitive behaviors, insistence on sameness, clinical psychology

Selected Publications

Mosconi, M. W, & Lejuez, C. W (n.d.). Making the brain matter in assessing and treating adolescent substance use – a commentary on Conrod and Nikolaou. Journal of Child Psychology and Psychiatry

Schmitt, L. M., Ankeny, L. D., Sweeney, J. A., & Mosconi, M. W. (2016). Inhibitory Control Processes and the Strategies That Support Them during Hand and Eye Movements. Frontiers in Psychology, 7, 1927. DOI:10.3389/fpsyg.2016.01927

Wang, Z., Hallac, R. R., Conroy, K. C., White, S. P., Kane, A. A., Collinsworth, A. L., Sweeney, J. A., & Mosconi, M. W. (2016). Postural orientation and equilibrium processes associated with increased postural sway in autism spectrum disorder (ASD). Journal of Neurodevelopmental Disorders, 8(43). DOI:10.1186/s11689-016-9178-1

D'Cruz, A., Mosconi, M. W, Ragozzino, M. E, Cook, E. H, & Sweeney, J. A (2016). Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorder. Translational Psychiatry, 6(10), e916. DOI:10.1038/tp.2016.161

Neely, K. A., Mohanty, S., Schmitt, L. M., Wang, Z., Sweeney, J. A., & Mosconi, M. W. (2016). Motor memory deficits contribute to motor impairments in autism spectrum disorder . Journal of Autism and Developmental Disorders. DOI:10.1007/s10803-016-2806-5

Ethridge, L. E, White, S. P, Mosconi, M. W, Wang, J., Byerly, M. J, & Sweeney, J. A (2016). Reduced habituation of auditory evoked potentials indicated cortical hyperexcitability in Fragile X Syndrome. Translational Psychiatry, 6, e787. DOI:10.1038/tp.2016.48

Ouyang, M., Cheng, H., Mishra, V., Gong, G., Mosconi, M. W., Sweeney, J. A., Peng, Y., & Huang, H. (2016). Atypical age-dependent effects of autism on white matter microstructure in children 2-7 years. Human Brain Mapping, 37(2), 819-832. DOI:10.1002/hbm.23073

Mosconi, M. W., Wang, Z., Tsai, P. T., & Sweeney, J. A. (2015). The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders. Frontiers in Neuroscience, 9(296). DOI:10.3389/fnins.2015.00296

Bishop, J. R., Najjar, F., Rubin, L. H., Guter, S. J., Owley, T., Mosconi, M. W., Jacob, S., & Cook, E. H. (2015). Escitalopram pharmacogenetics: CYP2C19 relationships with dosing and clinical outcomes in Autism Spectrum Disorder . Pharmacogenetics and genomics.

Najjar, F., Owley, T., Mosconi, M. W., Jacob, S., Hur, K., Guter, S., Sweeney, J., Gibbons, R., Cook, E., & Bishop, J. R. (2015). Pharmacogenetic study of serotonin transporter and 5HT2A genotypes in autism. Journal of Child and Adolescent Psychopharmacology, 467-74. DOI:10.1089/cap.2014.0158

Wang, Z., Magnon, G. C., White, S. P., Greene, R. K., Vaillancourt, D. E., & Mosconi, M. W. (2015). Individuals with autism spectrum disorder show abnormalities during initial and subsequent phases of precision gripping. Journal of Neurophysiology, 113(7), 1989-2001. DOI:10.1152/jn.00661.2014

Miller, H. L., Ragozzino, M. E., Cook, E. H., Sweeney, J. A., & Mosconi, M. W. (2015). Cognitive set shifting deficits and their relationship to repetitive behaviors in autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(3), 805-15. DOI:10.1007/s10803-014-2244-1

Mosconi, M. W., Mohanty, S., Greene, R., Cook, E. H., Vaillancourt, D. E., & Sweeney, J. A. (2015). Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder. Journal of Neuroscience, 35(5), 2015-2025. DOI:10.1523/JNEUROSCI.2731-14.2015

Schmitt, L. M., Cook, E. H., Sweeney, J. A., & Mosconi, M. W. (2014). Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in both cerebellum and brainstem. Molecular Autism, 5(1), 47. DOI:10.1186/2040-2392-5-47

Mosconi, M. W., Luna, B., Kay-Stacey, M., Nowinski, C. V., Rubin, L. H., Scudder, C., Minshew, N., & Sweeney, J. A. (2013). Saccade adaptation abnormalities implicate dysfunction of cerebellar-dependent learning mechanisms in autism spectrum disorders (ASD) . PLOS One, 8(5). DOI:10.1371/journal.pone.0063709

D’Cruz, A. M., Ragozzino, M. E., Mosconi, M. W., Cook, E. H., & Sweeney, J. A. (2013). Reduced behavioral flexibility in autism spectrum disorders is related to insistence on sameness. Neuropsychology, 27(2), 152-160. DOI:10.1037/a0031721

Mosconi, M. W., & Sweeney, J. A. (2012). Cerebellar dysfunctions underlying core cognitive and sensorimotor deficits in autism spectrum disorder. Cerebellum, 11(3), 777-807. DOI:10.1007/s12311-012-0355-9

Mosconi, M. W., Takarae, Y., & Sweeney, J. A. (2011). Motor impairments and dyspraxia in autism. In D. G. Amaral, G. Dawson, & D. H. Geschwind (Eds.), . Autism Spectrum Disorders. New York, NY: Oxford University Press, Inc.

D’Cruz, A. M., Mosconi, M. W., Ragozzino, M. E., Pavuluri, M., & Sweeney, J. A. (2011). Human reversal learning under conditions of certain versus uncertain outcomes. NeuroImage, 56, 315-322. DOI:10.1016/j.neuroimage.2011.01.068

Mosconi, M. W., Kay, M., D’Cruz, A. M., Guter, S., Kapur, K., Macmillan, C., Stanford, L. D., & Sweeney, J. A. (2010). Neurobehavioral abnormalities in first-degree relatives of individuals with autism. JAMA Psychiatry, 67, 830-840. DOI:10.1001/archgenpsychiatry.2010.87

D’Cruz, A. M., Mosconi, M. W., Steele, S., Rubin, L., Khine, T., & Sweeney, J. A. (2009). Lateralized response timing deficits in autism. Biological Psychiatry, 66, 393-397. DOI:10.1016/j.biopsych.2009.01.008

Mosconi, M. W., Hazlett, H. C., Poe, M., Gerig, G., Gimpel, R. S., & Piven, J. (2009). A longitudinal study of amygdala volume and joint attention in 2-4 year old children with autism. JAMA Psychiatry, 66, 509-516. DOI: 10.1001/archgenpsychiatry.2009.19

Selected Presentations

DeStefano, L., Wang, J., White, S., Mosconi, M., Sweeney, J. & Ethridge, L. (11/30/2016). Auditory neural oscillatory synchronization abnormalities across the gamma frequency range in autism spectrum disorder. Society for Psychophysiological Research. Minneapolis, MN

Ethridge, L., White, S., Mosconi, M., Wang, J., Erickson, C., Byerly, M. & Sweeney, J. (11/30/2016). Neural synchronization deficits linked to cortical hyper-excitability and auditory sensitivity in Fragile X Syndrome. Society for Psychophysiological Research. Minneapolis, MN

Mosconi, M. (11/30/2016). Understanding autism: stories of politics, fads and the brain. University of Kansas Nu Rho Psi Honor’s Society. Lawrence, Kansas

Mosconi, M. (10/31/2016). Motor and sensory disturbances and their brain bases in autism spectrum disorder. University of Kansas Child Language Program Professional Seminar Series. Lawrence, Kansas

Mosconi, M., Schmitt, L., White, S. & Sweeney, J. (09/30/2016). Brain system abnormalities associated with reduced control of sustained and repetitive motor behaviors. National Conference in Clinical Child and Adolescent Psychology (NCCCAP). Lawrence, KS

Wang, Z., Hallac, R., Conroy, K., White, S., Kane, A., Collinsworth, A. & Mosconi, M. (09/30/2016). Postural orientation and equilibrium are manifested in autism spectrum disorder (ASD). National Conference in Clinical Child and Adolescent Psychology (NCCCAP). Lawrence, KS

Schmitt, L., White, S., Sweeney, J. & Mosconi, M. (09/30/2016). Sensorimotor Abnormalities in Individuals with Autism Spectrum Disorder and Their Biological Parents. National Conference in Clinical Child and Adolescent Psychology. Lawrence, KS

Mosconi, M. (07/31/2016). What we think we think about thinking in Phelan-McDermid Syndrome. First Annual Phelan-McDermid Syndrome National Meeting (McPosium). . Orlando, FL

Mosconi, M., Schmitt, L., White, S. & Sweeney, J. (05/31/2016). Brain system abnormalities associated with reduced control of sustained and repetitive motor behaviors in autism. International Meeting for Autism Research (IMFAR). Baltimore, MD

Kwon, M., Mohanty, S., Conroy, K. & Mosconi, M. (05/31/2016). Increased Force Variability in Autism Reflects Reduced Modulation of Motor Neuron Pool Beta Oscillations. International Meeting for Autism Research (IMFAR). Baltimore, MD

Wang, Z., Hallac, R., Conroy, K., White, S., Kane, A., Collinsworth, A. & Mosconi, M. (05/31/2016). Postural control mechanisms underlying reduced stability in autism spectrum
disorder (ASD). International Meeting for Autism Research (IMFAR). Baltimore, MD

Schmitt, L., White, S., Conroy, K., Sweeney, J. & Mosconi, M. (05/31/2016). Sensorimotor abnormalities in biological mothers and fathers of individuals with ASD. International Meeting for Autism Research (IMFAR). Baltimore, MD

Mosconi, M. (04/30/2016). Characterizing the development of fundamental sensorimotor abilities and underlying brain systems in autism spectrum disorder. Department of Psychiatry Grand Rounds - Vanderbilt University. Department of Psychiatry Grand Rounds - Vanderbilt University

Mosconi, M., Schmitt, L., White, S., Conroy, K. & Sweeney, J. (12/31/2015). Familiality of sensorimotor alterations in autism spectrum disorder. American College of Neuropsychopharmacology (ACNP). Hollywood, FL

Mosconi, M. (11/30/2015). Moving towards more effective treatments for autism spectrum disorders. Annual Retreat for the University of Kansas Medical Center Department of Pediatrics. Kansas City, KS

Mosconi, M. (10/31/2015). Understanding the neurobiology of autism spectrum disorders through clinical research. Beyond the Diagnosis: Autism Across the Life Span. Kansas City, KS

Mosconi, M. (06/30/2015). Clinical and translational approaches for understanding Phelan-McDermid Syndrome. Texas-Louisiana Phelan-McDermid Syndrome Conference. Houston, TX

Mosconi, M., Vaillancourt, D. & Sweeney, J. (05/31/2015). Cerebellar alterations underlying visuomotor deficits in autism. Presentation, International Meeting for Autism Research (IMFAR). Salt Lake City, UT

Schmitt, L., White, S., Conroy, K., Sweeney, J. & Mosconi, M. (05/31/2015). Eye movement abnormalities in individuals with autism and their unaffected biological parents. Presentation, International Meeting for Autism Research (IMFAR). Salt Lake City, UT

Mohanty, S., Neely, K., Schmitt, L., Wang, Z., Vaillancourt, D., Sweeney, J. & Mosconi, M. (05/31/2015). Precision grip control with and without visual feedback in autism spectrum disorder. Presentation, International Meeting for Autism Research (IMFAR). Salt Lake City, UT

Wang, Z., Hallac, R., Conroy, K., Greene, R., White, S., Sweeney, J. & Mosconi, M. (05/31/2015). Sensory feedback mechanisms underlying postural control abnormalities in individuals with autism spectrum disorder (ASD). Presentation, International Meeting for Autism Research (IMFAR). Salt Lake City, UT

Ethridge, L., White, S., Mosconi, M., Wang, J., Byerly, M. & Sweeney, J. (05/31/2015). Sensory processing abnormalities, ASD features, and modulation of auditory evoked potentials in Fragile X Syndrome. Presentation, International Meeting for Autism Research (IMFAR). Salt Lake City, UT

Mosconi, M. (03/31/2015). Advancing care through research: How studies of brain and motor development in autism may lead to earlier diagnosis and more effective treatments. Inaugural Keynote Lecture, Friends of the Center for Autism and Developmental Disabilities. Dallas, TX

Mosconi, M. (01/31/2015). Translational approaches for identifying neural mechanisms in autism related disorders. Talk, University of Texas Southwestern Clinical Research Engagement Workgroup (CREW) Lunch Series. Dallas, TX

Mosconi, M., Vaillancourt, D. & Sweeney, J. (12/31/2014). Cortico-cerebellar dysfunctions associated with visuomotor abnormalities in autism spectrum disorder vary according to the quality of visual feedback. Presentation, American College of Neuropsychopharmacology (ACNP). Phoenix, AZ

Mosconi, M., Vaillancourt, D., Coombes, S. & Sweeney, J. (11/30/2014). Cortical-cerebellar abnormalities underlying visuomotor control deficits in autism spectrum disorder. Presentation, Society of Neuroscience (SfN). Washington, DC

Wang, Z., Magnon, G., Greene, R., Sweeney, J. & Mosconi, M. (11/30/2014). Predictive and reactive precision grip force control in individuals with autism spectrum disorder. Presentation, Society of Neuroscience (SfN). Washington, DC

Mosconi, M. (10/31/2014). Neuroscience and early detection of autism spectrum disorder. Talk, Psychiatry Continuing Education Program: Brain Stories, the Science Behind Prevention, Early Detection, and Effective Intervention for Mental Illness, Department of Psychiatry, University of Texas Southwestern. Dallas, TX

Mosconi, M. (09/30/2014). Cerebellar and sensorimotor development in autism. Talk, University of Minnesota Center for Cognitive Science (CCS) Colloquium Series. Minneapolis, MN

Mosconi, M. (09/30/2014). Profiles of sensorimotor impairments in autism spectrum disorder. Talk, University of Minnesota Center for Neurobehavioral Development (CNBD) Colloquium Series. Minneapolis, MN

Mosconi, M. (07/31/2014). Sensorimotor and cerebellar abnormalities in Phelan-McDermid Syndrome. Talk, The 14th Annual Phelan-McDermid Syndrome Foundation Conference. Orlando, FL

Ouyang, M., Cheng, H., Gong, G., Mosconi, M., Sweeney, J., Peng, Y. & Huang, H. (05/31/2014). Abnormal WM microstructural trajectories of autistic children from 2 to 7 years of age. Presentation, The International Society for Magnetic Resonance in Medicine (ISMRM). Milan, Italy

Schmitt, L., Mosconi, M., Ragozzino, M., Cook, E. & Sweeney, J. (05/31/2014). Neurocognitive strategies supporting behavioral response inhibition in autism spectrum disorder. Presentation, International Meeting for Autism Research (IMFAR). Atlanta, GA

Mosconi, M. (01/31/2014). Examining the effects of premutations and full mutations of the FMR1 gene on behavior and brain function. Talk, The Center for Autism and Developmental Disabilities (CADD) Annual Fragile X Day, UT Southwestern and Children’s Medical Center. Dallas, TX

Selected Grants

Huber, K., (Principal), Sweeney, J. A., (Principal), Mosconi, M. W., (Co-Investigator), Mechanisms of Neocortical and Sensory Hyperexcitability in Fragile X Syndrome, U54 Centers for Collaborative Research in Fragile X (NICHD), (09/01/2014 - 08/31/2019) . Federal. Status: Funded.

Sahin, M., (Principal), Mosconi, M. W., (Co-Investigator), Rare Diseases Clinical Research Network: Developmental Synaptopathies Consortium, NIH/NINDS, (01/01/2014 - 08/31/2019) . Federal. Status: Funded.

Mosconi, Matthew W, (Principal), Kansas Center for Autism Research and Training Research Investment Council Strategic Initiative Grant, (08/18/2015 - 08/17/2018) . State of Kansas. Status: Funded.

Versalovic, J., (Principal), Mosconi, M. W., (Co-Investigator), Establishing Multi-omic Signatures and Mechanisms Associated with GI Morbidity and Behavior in ASD, Autism Speaks, (12/01/2014 - 11/30/2017) . Private. Status: Funded.

Powell, Craig, (Co-Principal), Mosconi, Matthew W, (Consultant), Natural History Characterization of Individuals with Phelan-McDermid Syndrome, Phelan-McDermid Syndrome Foundation, (08/01/2015 - 07/31/2017) . Foundation. Status: Funded.

Mosconi, M. W., (Principal), Neurophysiological biomarkers associated with Phelan-McDermid Syndrome, Novartis, (07/01/2015 - 06/30/2017) . For Profit (company/corporation). Status: Funded.

Mosconi, Matthew W, (Co-Principal), Auditory and visual evoked potentials in Phelan-McDermid Syndrome, Phelan-McDermid Syndrome Foundation, (01/01/2016 - 12/31/2016) . Other. Status: Funded.

Mosconi, M. W., (Principal), Motor Control and Cerebellar Mechanisms in Fragile X-Associated Tremor/Ataxia Syndrome, Once Upon A Time Foundation, (09/01/2013 - 11/30/2015) . Foundation. Status: Funded.

Mosconi, M. W., (Principal), Motor Control and Cerebellar Maturation in Autism, K23 MH092696-01, NIH/NIMH, (09/01/2010 - 11/30/2015) . Federal. Status: Funded.

Sweeney, J. A., (Principal), Mosconi, M. W., (Co-Investigator), Family Studies of Neurocognitive and Sensorimotor Heterogeneity in Autism, AR100276, Dept of the Army, (09/01/2011 - 07/31/2015) . Federal. Status: Funded.

Cook, E. H., (Principal), Mosconi, M. W., (Co-Investigator), Autism Center of Excellence: Translational Studies of Insistence on Sameness in Autism, P50 HD055751-01, NICHD/NIMH, (09/01/2007 - 07/31/2013) . Federal. Status: Funded.


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